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pentobarbital will reduce the extent or impact of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.pentobarbital will lessen the extent or influence of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.네덜란드의 경우, 의사조력 자살의 표�